In RA, CRD are linked to immune dysregulation, particularly involving key circadian rhythm genes (CRGs) like NFIL3, which are upregulated in RA and correlate with pro-inflammatory pathways such as TNF-α/NF-κB, IL-17, IL-6, IL-1β, and Matrix Metalloproteinase 3 (MMP3). This evidence concerns the gene NFIL3 and rheumatoid arthritis.