M1 Spastin-ABCD1 recruits ESCRT-III proteins to promote FA trafficking from LDs to peroxisomes. The herbal formula JTTZF ameliorates hepatic steatosis and oxidative stress in HFD-induced MASLD mice by targeting the Pex-LD interface (e.g., downregulating ABCD2, an ABCD1 homolog). Here, ABCD2 is linked to fatty liver disease.