Phase II clinical trials confirm DGAT2 inhibition (ION224) significantly improves liver steatosis and histology in MASH patients. Animal models show DGAT2 inhibition increases ER phosphatidylethanolamine (PE) levels, suppressing SREBP-1c cleavage and lipogenesis. Cellular models indicate Seipin loss reduces cholesterol-mediated large LD formation and alleviates ER stress. The gene discussed is DGAT2; the disease is fatty liver disease.