Immunohistochemical results from the Human Protein Atlas (HPA) database suggested decreased protein expression levels of CD38 in prostate cancer tissues (Supplementary Figures S3A,B), while MMP11 (Supplementary Figures S3C,D) and PLK1 (Supplementary Figures S3E,F) showed moderate expression in both normal and cancerous tissues. The gene discussed is PLK1; the disease is Familial prostate cancer.