Pan-cancer analysis (based on the SangerBox database) showed that PLK1 was significantly upregulated in the vast majority of cancer types (Figure 4D), and its high expression was significantly associated with poor progression-free survival in various tumors, including GBMLGG, KIPAN, KIRP, KIRC, PRAD, LGG, ACC, KICH, LIHC, PAAD, MESO, UAM, LUAD, BRCA, THCA, SKCM-M, SARC, SKCM, and BLCA (Supplementary Figure S4). This evidence concerns the gene PLK1 and cancer.