Abbreviations: AEMPS: Agencia Española de Medicamentos y Productos Sanitarios; BEVA: bevacizumab; CRC: colorectal cancer; EGFR: anti-epidermal growth factor receptor; EMA: European Medicines Agency; EVIDEM: evidence and value: impact on decision-making; FTD/TPI: trifluridine/tipiracil; HRQoL: health-related quality of life; ISPOR: international society for pharmacoeconomics and outcomes research; MCDA: multicriteria decision analysis; mCRC: metastatic colorectal cancer; SD: standard derivation; Sx: standardised score; VEGF: anti-vascular endothelial growth factor; Vx: value contribution. The gene discussed is EGFR; the disease is colorectal cancer.