The predicted BL2.2 epitope is in strong agreement with the established GM1 receptor-binding pocket of both LT and CTX, greatly conserved among hLTB and porcine LTB (pLTB), as well as the ctxB genotypes (ctxB1, ctxB3, and ctxB7) associated with all cholera pandemics to date (Fig. S8).14 This evidence concerns the gene LTA and vibrio infectious disease.