Moreover, it has been found that the nuclear accumulation of KPNA2 influences radio-resistance through positive regulation of the PLSCR1–STAT1 loop in lung adenocarcinoma [21], whereas the IMPDH1/YB-1 positive feedback loop is associated with the assembly of cyto-ophidia and is considered a promising therapeutic target in metastatic tumors [22]. Here, STAT1 is linked to metastatic neoplasm.