In NSCLC, a downregulation of KPNA2 leads to the downregulation of Oct4, thereby inhibiting cell proliferation [26], and miR-101 has been demonstrated to target KPNA2 to inhibit the progression of lung squamous cell carcinoma cell lines [27], whereas hsa_circ_0022383 promotes NSCLC tumorigenesis by regulating the miR-495–KPNA2 axis and the knockdown of KPNA2 has similarly been found to inhibits the proliferation and migration of lung cancer cells [28]. This evidence concerns the gene POU5F1 and squamous cell lung carcinoma.