Similarly, the CENPU/E2F6/E2F1 positive feedback loop promotes proliferation and metastasis via the ubiquitination of E2F6 in HCC [19] and that of FAM83A/PI3K/AKT/c-Jun promotes migration, invasion, and metastasis in HCC [20]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.