KPNA2 and lung adenocarcinoma: To establish whether KPNA2 influences the proliferation of lung adenocarcinoma, cells we knocked down the expression of this protein in A549 and H1299 cells using two different siRNAs and sought to verify the efficiency of silencing by performing qRT–PCR and western blot analyses, The results of qRT–PCR (Fig. 2A) and western blotting (Fig. 2B) accordingly revealed a significant suppression of KPNA2 expression.