In addition, analysis of the TREM1+ PMN-MDSCs population revealed that TREM1 exhibited high expression in multiple cancers, including renal cell carcinoma (RCC), pancreatic ductal adenocarcinoma (PDAC), gastric cancer (GC) and lung cancers (LC) (Fig. 4F). This evidence concerns the gene TREM1 and laryngotracheoesophageal cleft.