HIF1A and nonpapillary renal cell carcinoma: Loss of pVHL tumor suppressor, which is found in a familial angiomatous syndrome and the majority of sporadic cases of hemangioblastoma and clear-cell renal cell carcinoma (ccRCC), is the typical example that results in HIF-1α subunit stabilization due to lack of Cul2 ubiquitylation complex recognition8.