NPM1 and colorectal carcinoma: Like ISRIB and PERK inhibition, trazodone hydrochloride treatment restored short-term proliferation in ApcloxP/loxPNpm1loxP/loxP intestinal cells and significantly reduced the survival benefit from Npm1 deletion in the ApcloxP/+KrasG12D/+ CRC model (Extended Data Fig. 9o–r).