Consistent with a previous report that E. coli inhibited SLC7A11/GPX4 signalling in BMECs [12], infection with E. coli resulted in the inhibition of SLC7A11 and GPX4 expression in endometrial tissue and BEECs, which may be responsible for the imbalance in redox homeostasis in this study. The gene discussed is GPX4; the disease is infection.