Established quantitative MRI (qMRI) techniques, including diffusion tensor imaging (DTI) metrics (mean diffusivity, MD, and fractional anisotropy, FA) and relaxometry indices (longitudinal relaxation time, T1, and transverse relaxation time, T2), enable assessment of differences in CP microstructural integrity with aging, obesity, and markers of neuroinflammation and AD pathology [17–21]. The gene discussed is CP; the disease is Alzheimer disease.