On univariate analysis, significant risk factors for in-hospital mortality included older age (p < 0.001), aortic prosthetic endocarditis (p < 0.001), periannular abscess (p = 0.002), SAPVE (p < 0.001), NYHA functional class III/IV (p = 0.02), previous combined coronary artery bypass-grafting (CABG) with valve replacement surgery (p = 0.02), left ventricular dysfunction (p < 0.001), leukocytosis (p = 0.02) and higher C-reactive protein levels (p = 0.006), as presented in Table 4. This evidence concerns the gene CRP and Increased total leukocyte count.