MUC16/CA125 expression is almost universal in high grade serous ovarian cancers making it an attractive potential target.19 MUC16/CA125 is composed of 3 major domains and subdomains; a heavily glycosylated large extracellular region including an N-terminal portion, a tandem-repeated domain, and a carboxyl-terminal domain that can be divided into an additional three subdomains composed of an ectodomain, the transmembrane, and a cytoplasmic-tail. Here, MUC16 is linked to ovarian serous adenocarcinoma.