ABCB1 and breast cancer: In-silico ADMET profiling (contextual, not in-vivo PK) highlighted superior oral absorption and BBB penetration for BC and negligible oral uptake for DOX; docking predicted higher DOX affinities across Bcl-2, β-catenin, P-glycoprotein, and topoisomerase II (e.g., − 9.06 to − 9.30 kcal mol−1) relative to BC (≈ − 7.6 to − 7.8 kcal mol−1).