A similar NE variant within the SCLC-A ASCL1-positive subtype, ASCLC-Aσ, was identified in human and mouse SCLC metastases samples and also presented with loss of neuronal identity, controlled by Sox1 and Nkx2-1 (also known as TTF-1)52. Here, NKX2-1 is linked to small cell lung carcinoma.