CASP8 and neoplasm: In support of the notion that the RP-mouse model of SCLC does not sufficiently mimic absent caspase 8 expression and, hence, does not spontaneously allow for necroptosis-associated inflammation, RP-MlklAA/AA mice did not show a significant difference in tumor incidence and Kaplan–Meier survival nor showed any changes in tumor-associated immune infiltration (Supplementary Fig. 11a–d).