Interestingly, using bioinformatic tumor purity estimates19 from whole genome sequencing (WGS) data of human SCLC patient samples (n = 70)20, we found that tumor purity negatively correlates with detected caspase 8 expression within human SCLC biopsies indicating that residual caspase 8 expression detected in bulk RNA-sequencing data from a minority of patients likely derives from non-tumor contaminants (i.e., immune cell, normal lung cells) (Supplementary Fig. 1b). Here, CASP8 is linked to small cell lung carcinoma.