Moreover, in a recently described single cell RNA-seq dataset depicting temporal plasticity from ASCL1+ mouse SCLC to non-NE YAP1+ SCLC34, caspase 8 expression also did not follow a clear SCLC-A/N/P/Y subtype pattern (Supplementary Fig. 3d). This evidence concerns the gene YAP1 and small cell lung carcinoma.