CASP8 and small cell lung carcinoma: Interestingly however, adherent cell lines with non-neuroendocrine differentiation derived from the widely used genetically engineered mouse model for SCLC (RP-mice)23 did not show lower caspase 8 mRNA expression than cell lines derived from KrasG12D/Trp53-deletion driven NSCLC (KP-mice)24 despite the same genetic background of both mouse models (C57BL/6) (Fig. 1f).