Yang et al. demonstrated that in CRC, upregulated NSUN4 catalyzed m5C methylation at positions 1114 and 1357 of NXPH4. This modification disrupts the interaction between NXPH4 mRNA and SQSTM1, thus preventing its degradation via RNautophagy. The gene discussed is NXPH4; the disease is colorectal carcinoma.