For instance, Chen et al. further found that in colorectal cancer (CRC), lactate accumulation, due to glycolysis and lactate production increased, On the one hand, promotes NSUN2 transcription through H3K18 lactylation, On the other hand, and lactate also induces NSUN2 lactylation at the Lys356 (K356) to enhance NSUN2 activity, creating a positive feedback loop that supports tumor growth and metastasis [83]. Here, NSUN2 is linked to colorectal cancer.