For example, circACACA facilitated colorectal tumorigenesis by regulating the miR-193a/b-3p/HDAC3/p53 axis to activate the MVA pathway [50]; circACACA enhanced migration, invasion, proliferation and glycolysis of cervical cancer cells by acting as sponges of miR-582-5p [51]; circACACA impaired the cellular functions of non-small cell lung cancer cells, including proliferation, invasion, and migration, via regulation of the miR-1183 and PI3K/AKT signaling pathways [52]. Here, TP53 is linked to non-small cell lung carcinoma.