TMEM43 and arrhythmogenic right ventricular cardiomyopathy: Decreasing interaction of VDAC2 and TMEM43 in mutant cells may change the cellular localization of VDAC2 [34] and influence mitochondrial Ca2+ uptake, leading to effects like arrhythmia, fibrosis that are found in TMEM43 S358L associated ARVC.