In addition, several non-desmosomal genes including Tmem43, Desmin (DES) [6,7], Integrin linked kinase (ILK) [8], Filamin C (FLNC) [9], LEM domain containing protein 2 (LEMD2) [10] have been reported to be associated with ARVC. Here, TMEM43 is linked to arrhythmogenic right ventricular cardiomyopathy.