Multivariate analysis revealed alpha-fetoprotein ≥500 ng/mL (HR = 1.881, 95% CI: 1.028–3.443, p = 0.04), tumor size (HR = 1.833, 95% CI: 1.010–3.327, p = 0.046) and ATEZO/BEV therapy (HR = 0.604, 95%CI: 0.373–0.977, p = 0.04) were independently associated with OS. The gene discussed is AFP; the disease is neoplasm.