Therefore, they suggested that based on the obtained results on inflammasome components along with increased expression of IL-1β especially in overweight patients, it can be concluded that IL-18 expression as well as IL-1β is probably due to activation of Absent in Melanoma 2 (AIM2), NALP3 or NLR family apoptosis inhibitory protein (NAIP) inflammasome, which may play a critical role in immunopathology of PCOS [19]. This evidence concerns the gene IL1B and polycystic ovary syndrome.