IL1B and obesity due to melanocortin 4 receptor deficiency: We observed the significant elevation of IL-1β expression levels in PCOS patients with both BMI > 25 kg/m2 and BMI < 25 kg/m2 Pre-treatment suggests a heightened inflammatory state in PCOS, regardless of obesity status IL-1β, a key pro-inflammatory cytokine involved in inflammasome activation, plays a significant role in the pathophysiology of PCOS by exacerbating chronic inflammation, insulin resistance, and metabolic dysregulation.