Several biological mechanisms may underlie the reduced muscle strength observed in adults with asthma–chronic systemic inflammation (IL-6, TNF-α) [51,52], intermittent hypoxia with ventilatory limitation during exacerbations [53], physical deconditioning driven by fear of dyspnea [53], and steroid-induced myopathy with prolonged corticosteroid exposure [54,55]. Here, TNF is linked to myopathy.