ITGA3 and hepatocellular carcinoma: This analysis identified 18 protein-encoding genes for which expression correlated with 90Y resistance across all cell lines (EN score >0.7), including ITGA3 (EN score = 0.911, R = 0.79), a subunit of the α3β1 integrin heterodimeric complex implicated in HCC progression and immune checkpoint expression (Fig. 3A).