While UNC93B1 p.Ile317Met (c.325G >C) associates with gain of TLR7 activity and jSLE, UNC93B1 p.Leu330Arg, p.Arg466Ser, and p.Arg525Pro primarily associate with gain of TLR8 activity, isomorphic TLR7 activity and familial chilblain lupus [36]. This evidence concerns the gene TLR7 and familial chilblain lupus.