Moreover, in the UK JSLE cohort, genetic variability at several SLE-associated genes (namely ACP5, ITGAM, LYN, TNFAIP3) associated with high disease activity in pediatric BILAG organ domains (e.g., kidney disease and ACP5, ITGAM, LYN, TNFAIP3), suggesting exploitation of this approach to predict organ involvement/outcomes [88]. This evidence concerns the gene ITGAM and systemic lupus erythematosus.