This recognition of the engineered MCF-7 was further investigated in tumor cell killing assays where autologous PBL transduced with the 4211_TCR-1 suppressed (p = 0.0065) the growth of the MCF-7 cell line only when the appropriate HLA-DRB1*04:01 but not when the control HLA-A*03 was introduced (Fig. 3I, Suppl. This evidence concerns the gene HLA-DRB1 and neoplasm.