CD8A and neoplasm: Interestingly, OBP-702 has the potential to strongly activate antitumor immunity even in pancreatic cancer, a representative cold tumor, by inducing immunogenic cell death, activating dendritic cells, facilitating the recruitment of CD8 + T cells, activating memory T cells, and suppressing myeloid-derived suppressor cells and cancer-associated fibroblasts [20–23].