In the analysis of antitumor immunity using the tumor tissues of the orthotopic and metastatic sites harvested 14 days after the first OBP-702 injection, the combination therapy of butyrate and OBP-702 significantly increased CD8 + T cells, CD8 + IFN-γ + T cells, and Granzyme B expression in the orthotopic tumors and the liver metastases compared with butyrate monotherapy. The gene discussed is GZMB; the disease is neoplasm.