NLRC5 and neoplasm: In a CT26 subcutaneous tumor model, butyrate significantly increased NLRC5 expression, a key regulator of MHC-I, selectively in the tumor tissue, but not in the other organs such as the ileum, liver, and skin, which led to the upregulation of MHC-I in the tumor tissue alone, with no significant effect on the ileum, liver, and skin (Fig. 3H).