IFITM5 and osteogenesis imperfecta type 5: A different heterozygous mutation in IFITM5 (c.119C > T) results in the so-called atypical OI type V. This mutation affects two palmitoylation sites of BRIL (S50 and S51 in humans, S52 and S53 in mice) that causes poor palmitoylation of the protein that is retained in the Golgi [218].