GSDMB and asthma: Our findings establish GSDMB as an executor of pyroptosis that guards the mucosal interface against coronavirus infection and unveils a novel viral strategy to circumvent this defense, highlighting new avenues for therapeutic intervention against coronaviruses.IMPORTANCEWhile gasdermin B (GSDMB) is genetically associated with mucosal inflammatory diseases like asthma, its function in host defense at mucosal barriers remains an open question.