SPAG6 and male infertility: SPAG6 is crucial for maintaining normal ciliary structureand function, and its loss has been associated with brain edema inmice., While SPAG6 deficiency leads to male infertility,female mice remain fertile, although fertilization is delayed, suggestingan impact on the motile cilia in the oviduct. In this study, SPAG6 showed widespread expression across the wholecell in nasopharynx, bronchus and fallopian tube, while its localizationwas more restricted to CL and TZ in endometrium and cervix (Figure D).