introduced functional groups such as tumor-targeting peptide cRGD, cell-penetrating and lysosomal escape peptide 9 R, and redox-responsive disulfide bonds into polyacrylamide nanohydrogels, which could successfully release STAT3 siRNA response into CT26, promoting STAT3 gene silencing and inhibiting cancer cell proliferation (Figure 6) (Yu et al., 2024). This evidence concerns the gene STAT3 and neoplasm.