IRS1 and neoplasm: In addition, upregulation of p‐AKT in Exos‐treated tumours was reversed by BKM120, whereas downregulation of KLF13 and upregulation of miR‐3126‐5p, SH2B1, IRS1, and p‐PI3K caused by Exos were not affected by BKM120 co‐administration (Figure S8F,G).