Knockdown of exosomal miR‐3126‐5p derived from CAFs reversed the downregulation of KLF13 and upregulation of SH2B1 and IRS1 in Exos‐treated NSCLC cells, and these changes were abrogated by KLF13 knockdown in NSCLC cells (Figure S6B). This evidence concerns the gene IRS1 and non-small cell lung carcinoma.