Besides, glucose consumption (Figure S4A), lactate production (Figure S4B), and ECAR (Figure S4C) were attenuated, but OCR (Figure S4D) was enhanced in IRS1‐depleted NSCLC cells, whereas these alterations were partly abolished by SH2B1 overexpression (Figure S4A–D). The gene discussed is SH2B1; the disease is non-small cell lung carcinoma.