To assess CAFs' impact on tumour invasion in vivo, we created orthotopic xenografts using nude mice randomized into four groups: (a) CAL27; (b) CAL27 + WT CAFs; (c) CAL27 + WT CAFs treated with 3‐MA; (d) CAL27 + SRGN‐KO CAFs. This evidence concerns the gene SRGN and neoplasm.