Our patient had marked improvement in upper and lower airway symptoms, with consistent reductions in nasal polyp burden, improved olfactory function, and decreased type 2 inflammation markers, as summarized in Figure 1. TSLP has been reported to be highly expressed in both eosinophilic and non-eosinophilic nasal polyps [6], with elevated expression at both the mRNA and protein levels in nasal polyps of patients with CRSwNP, regardless of eosinophil counts [7]. The gene discussed is TSLP; the disease is chronic rhinosinusitis with nasal polyps.