The PubMed search string was constructed as follows: (“Renin”[MeSH Terms] OR “Renin Inhibitors”[MeSH Terms] OR “Direct Renin Inhibition” OR “Aliskiren” OR “Direct Renin Blockade”) AND (“Angiotensin-Converting Enzyme Inhibitors”[MeSH Terms] OR “ACE Inhibitors” OR “Angiotensin II Type 1 Receptor Blockers”[MeSH Terms] OR “ARBs” OR “Losartan” OR “Ramipril”) AND (“Hypertension”[MeSH Terms] OR “High Blood Pressure” OR “Essential Hypertension”) AND (“Randomized Controlled Trial”[Publication Type] OR “Clinical Trial”[Publication Type] OR “Observational Study” OR “Prospective Study”). This evidence concerns the gene ACE and essential hypertension.