The dramatic yet rapidly reversible aspartate aminotransferase/alanine aminotransferase surges (>1,000 IU/L) are consistent with data showing that severe hepatocellular elevations occur not uncommonly in choledocholithiasis and transient biliary obstruction and promptly improve once the biliary obstruction is relieved [8,9]. The gene discussed is GPT; the disease is choledocholithiasis.