To investigate whether RBM25 aggravates HF by promoting cardiomyocyte apoptosis through positive regulation of the p38 MAPK signaling pathway, we analyzed the expression levels of RBM25, pro‐apoptotic genes (Caspase‐3 and Bax), and the anti‐apoptotic gene (Bcl‐2) in myocardial tissues from eight groups of rats. The gene discussed is BCL2; the disease is hydrops fetalis.