MAP4K4 and heart failure: This graphical abstract illustrates how RBM25 exacerbates post‐infarction heart failure in rats by promoting exon 16 skipping in MAP4K4, generating a truncated isoform (MAP4K4‐Δ16) that enhances MAP3K1 binding and activates the p38 MAPK pathway, leading to increased cardiomyocyte apoptosis via upregulated Caspase‐3 and Bax and downregulated Bcl‐2.