In RBM25‐overexpressing models, p38 MAPK inhibition with SB203580 did not result in statistically significant changes in HF biomarkers (NT‐proBNP, CRP, IL‐6, and TNF‐α; p > 0.05), which may reflect the study's limited statistical power due to small sample size. Here, NPPB is linked to hydrops fetalis.