To investigate whether RBM25 aggravates HF by promoting cardiomyocyte apoptosis through positive regulation of the p38 MAPK signaling pathway, we analyzed the expression levels of RBM25, pro‐apoptotic genes (Caspase‐3 and Bax), and the anti‐apoptotic gene (Bcl‐2) in myocardial tissues from eight groups of rats. This evidence concerns the gene RBM25 and hydrops fetalis.