SNCA and Parkinson disease: The essence of Parkinson’s disease (PD) is a neurodegenerative disease, and its pathogenesis is closely related to mitochondrial dysfunction, oxidative stress, α-synuclein aggregation, and abnormal glycosylation modification, pathological manifestations are characterized by early and significant death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in classic Parkinson’s motor symptoms due to dopamine deficiency (Kalia and Lang, 2015).