TSLP, IL-33, and IL-25 bind to TSLPR, ST2, and IL-25R, respectively, and induce proinflammatory signaling cascades that contribute to the pathogenesis of inflammatory respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and chronic rhinosinusitis with nasal polyps (CRSwNP) (1, 3, 4). Here, IL33 is linked to chronic obstructive pulmonary disease.