TSLP, IL-33, and IL-25 bind to TSLPR, ST2, and IL-25R, respectively, and induce proinflammatory signaling cascades that contribute to the pathogenesis of inflammatory respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and chronic rhinosinusitis with nasal polyps (CRSwNP) (1, 3, 4). The gene discussed is IL1RL1; the disease is asthma.