IL25 and chronic obstructive pulmonary disease: TSLP, IL-33, and IL-25 bind to TSLPR, ST2, and IL-25R, respectively, and induce proinflammatory signaling cascades that contribute to the pathogenesis of inflammatory respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and chronic rhinosinusitis with nasal polyps (CRSwNP) (1, 3, 4).