Furthermore, even after multivariable adjustment for diabetes, alcohol consumption, antiarrhythmic drug use, SGLT2 inhibitor use, left atrial diameter (LAD), and uric acid levels, elevated SHR remained significantly associated with AF recurrence (HR: 3.379, 95% CI: 2.272–5.025, P < 0.001). This evidence concerns the gene SLC5A2 and atrial fibrillation.