In KS lesions with MCD, there was a notable decrease in RUNX3 ((log2FC= −1.1, padj= 0.04), PDCD1 (log2FC=−1.4, padj= 0.04), involved in T cell regulation and differentiation, CCR4 (log2FC= −1.4, padj= 0.04), involved in immune function, and CD45RA (log2FC= −1.2, padj= 0.04), involved in lymphocyte regulation and a suppressor of JAK kinases. The gene discussed is CCR4; the disease is Kaposi's sarcoma.