However, based on the metabolic health variables reported in studies with this information (see Descriptives Table) and, where available, considering primary criteria of either homeostatic model assessment of insulin resistance (HOMA-IR) ≥ 2.5 or secondary criteria including fasting insulin > 12μU/mL or fasting glucose ≥ 100mg/dL, all groups of women with PCOS in the included studies would be considered to have insulin resistance. This evidence concerns the gene INS and polycystic ovary syndrome.