APOE and Alzheimer disease: Analysis of intercellular signaling revealed distinct network patterns across cohorts, Non-AD APOE ε3/ε4 or ε4/ε4 females and APOE ε3/ε3 AD females exhibited balanced neuron-astrocyte-oligodendrocyte precursor communication networks; Conversely, APOE ε3/ε4 or ε4/ε4 female AD patients demonstrated three hallmark alterations: diminished neuron-to-glial signaling (Figures 8A,B), significantly enhanced endothelial communication, and elevated oligodendrocyte activity (Figures 8B,C).