To further explore the cross-relationship between gene modules—APOE ε4 and sex, we constructed correlation heatmap between four phenotypes and gene modules: FAD_APOE:ε3/ε3 or ε2/ε3 (female AD patient with APOE ε3/ε3 or ε2/ε3 genotype), MAD_APOE:ε3/ε3 or ε2/ε3 (male AD patient with APOE ε3/ε3 or ε2/ε3 genotype), FAD_APOE:ε3/ε4 (female AD patient with APOE ε3/ε4 genotype), and MAD _APOE:ε3/ε4 (male AD patient with APOE ε3/ε4 genotype) (Figure 1E). The gene discussed is APOE; the disease is Alzheimer disease.