To identify causal genes underlying AD pathogenesis from modules highly correlated with FAD (ε3/ε4) group (salmon2, skyblue, brown and honeydew1), we performed Summary-data-based Mendelian randomization (SMR) integrating GWAS and eQTL data, applying thresholds of PSMR<0.01 and PHEIDI>0.05 on 315 hub genes, we identified 10 genes with causal associations to AD progression (Table 1), including RBMS2, RFX2, KLF5, TMOD3 and LTBP2. Here, RFX2 is linked to Alzheimer disease.