Our analyses revealed significant positive correlations between hub genes (LAMC1, RBMS2, MYO1C, TMOD3, APOL3, NDNF, LRP10, LTBP2, CES1) and established measures of Alzheimer’s disease progression, specifically Braak stage and CDR score. The gene discussed is RBMS2; the disease is early-onset autosomal dominant Alzheimer disease.