Our analyses revealed significant positive correlations between hub genes (LAMC1, RBMS2, MYO1C, TMOD3, APOL3, NDNF, LRP10, LTBP2, CES1) and established measures of Alzheimer’s disease progression, specifically Braak stage and CDR score. This evidence concerns the gene LTBP2 and early-onset autosomal dominant Alzheimer disease.