Relative to female and male APOE ε3/ε3 AD patients, female APOE ε3/ε4 AD patients exhibited elevated expression levels of several hub genes, including MLTK, LAMC1, LRP10, MAPKAPK2, GIMAP5, KDELC2, HCP5 and HLA-B (FDR < 0.1), with MLTK, LAMC1 and GIMAP5 reaching a more stringent significance threshold (FDR < 0.05). The gene discussed is HLA-B; the disease is Alzheimer disease.