Heatmap analysis revealed that the human APOE ε4 allele significantly upregulated hub genes Lrp10, Ltbp2, Lamc1, Rbms2 etc., and the expression levels of tauopathy mice with APOE ε4 were higher than those of control mice with APOE ε4, revealing that these genes were also key genes associated with tau pathology (Figure 9A). The gene discussed is APOE; the disease is tauopathy.