To identify causal genes underlying AD pathogenesis from modules highly correlated with FAD (ε3/ε4) group (salmon2, skyblue, brown and honeydew1), we performed Summary-data-based Mendelian randomization (SMR) integrating GWAS and eQTL data, applying thresholds of PSMR<0.01 and PHEIDI>0.05 on 315 hub genes, we identified 10 genes with causal associations to AD progression (Table 1), including RBMS2, RFX2, KLF5, TMOD3 and LTBP2. This evidence concerns the gene LTBP2 and Alzheimer disease.