STAT6 and Hepatic fibrosis: Of note, egg-derived extracellular vesicles from Schistosoma japonicum contain Sja-miR-71a microRNA (miR) that inhibits both IL-13/STAT6 and Transforming growth factor (TGF)-β1/SMAD pathways via direct targeting of semaphorin 4D, leading to suppression of liver fibrosis by regulating the Th1/Th2/Th17/Treg balance (Wang et al., 2020).