While human STAT6 deficiency has not yet been identified, as it may not be viable, human STAT6 single nucleotide polymorphisms are associated with multiple allergic and non-allergic diseases (Sharma et al., 2023), including atopic dermatitis, multiple food allergies, anaphylaxis, asthma, allergic rhinitis, eosinophilic gastrointestinal diseases, lymphoproliferation, osteoporosis, cerebral aneurysms, renal fibrosis, short stature, and hypotrichosis (for review see (Tolomeo and Cascio, 2024; Sturvey and Consortium, 2024)). This evidence concerns the gene STAT6 and allergic disease.