By blocking the inflammatory signaling system in the hippocampal tissue of PPD rats specifically the arachidonic acid metabolic pathway and nuclear factor kappa-B (NF-κB), SJF appears to have an effect similar to that of sEH inhibitors, helping to reduce the symptoms of PPD (Jingya et al., 2024). The gene discussed is NFKB1; the disease is progressive pseudorheumatoid arthropathy of childhood.