Studies have shown that aberrant signaling in the central amygdala, involving lipid transport protein type prostaglandin D synthase (L-PGDS)/prostaglandin D2 (PGD2), disrupts Src protein phosphorylation, leading to astrocyte atrophy and ultimately resulting in PPD in mice (Sheng et al., 2024). The gene discussed is PTGDS; the disease is progressive pseudorheumatoid arthropathy of childhood.