By blocking the inflammatory signaling system in the hippocampal tissue of PPD rats specifically the arachidonic acid metabolic pathway and nuclear factor kappa-B (NF-κB), SJF appears to have an effect similar to that of sEH inhibitors, helping to reduce the symptoms of PPD (Jingya et al., 2024). This evidence concerns the gene EPHX2 and progressive pseudorheumatoid arthropathy of childhood.