The extreme elevations of markers for adenocarcinoma (CEA, CA19‐9), neuroendocrine tumours (NSE, ProGRP), squamous carcinoma (CYFRA, SCC), and hepato‐pancreato‐biliary cancer (PIVKA‐II, DUPAN‐2) naturally raised the differential diagnosis of synchronous primary cancers. The gene discussed is ENO2; the disease is cancer.