BTG3 and primary biliary cholangitis: In conclusion, our study emphasized the important role of ductopenia in the prognosis of PBC, suggesting that doctors should incorporate ductopenia into routine assessments, dynamically integrate histological information (stage/degree of ductopenia) with serum biological markers (GGT, TBIL, ALB, and ANA), comprehensively evaluate the patients’ disease status and progression risk, and optimize the management of patients with PBC.