Compared with those without ductopenia, patients with PBC and ductopenia had significantly higher levels of alanine transaminase (median: 49.00 vs 43.00U/L), aspartate transaminase (median: 64.00 vs 39.00 U/L), TBIL (median: 26.75 vs 14.60 μmol/L), direct bilirubin (median: 10.90 vs 5.30 μmol/L), total bile acid (median: 33.75 vs 9.70 μmol/L), ALP (median: 216.50 vs 132.50 U/L), GGT (median: 209.00 vs 107.50 U/L), IgM (median: 3.52 vs 2.65 g/L), ANA, AMA, and Anti-gp210, as well as longer prothrombin time (mean: 16.68 vs 16.02 s) (all P values < 0.05). The gene discussed is F2; the disease is primary biliary cholangitis.