Conversely, patients with PBC and ductopenia had significantly lower levels of ALB (mean: 38.24 vs 42.90 g/L), cholinesterase (median: 4537.00 vs 6835.00 U/L), prothrombin activity (mean: 96.90 vs 103.40%), RBC (mean:3.75 vs 4.31×1012/L), PLT (mean:176.00 vs 227.00 ×109/L), and hemoglobin (mean: 112.96.00 vs 128.20×109g/L) (all P values < 0.05). The gene discussed is F2; the disease is primary biliary cholangitis.