As reported in Figure 2B, the serum VEGF levels significantly increased in patients with SSc (mean = 3,823 ± 1,664 pg/ml, median = 3,952 pg/ml, range = 5,980 pg/ml) compared with the healthy controls (mean = 1,736 ± 801 pg/ml, median = 1,599 pg/ml, range = 1,696 pg/ml). This evidence concerns the gene VEGFA and systemic sclerosis.