Lower circulating uPA (3,226 ± 2,444 pg/ml) and higher PAI-1 (95.30 ± 22.80 ng/ml) and suPAR (2.522 ± 1.186 ng/ml with Human suPAR ELISA and 3.835 ± 2.944 ng/ml with suPARnostic ELISA) levels were found in patients with SSc. Here, PLAU is linked to systemic sclerosis.