As shown in Figure 3E, no significant difference was detected in the serum uPA between patients with the SSc-active pattern (mean = 3,414 ± 2,895 pg/ml, median = 3,763 pg/ml, range = 6,437 pg/ml) and those with the SSc-late pattern (mean = 3,576 ± 2,173 pg/ml, median = 3,512 pg/ml, range = 6,403 pg/ml). The gene discussed is PLAU; the disease is systemic sclerosis.