A negative correlation between uPA and activated TGF-β1 (Spearman’s ρ = −0.52, p=0.008, BH-adjusted p=0.04) was found in the sera of patients with SSc, whereas a positive correlation was observed between PAI-1 and VEGF (Spearman’s ρ = 0.48, p=0.01, BH-adjusted p=0.05). This evidence concerns the gene PLAU and systemic sclerosis.