In contrast, analysis of PAI-1 (reported in Figure 3F) showed that, in patients with the SSc-late pattern (mean = 103.2 ± 15.47 ng/ml, median = 106.5 ng/ml, range = 58.00 ng/ml), the serum levels were significantly higher than in those with the SSc-active pattern (mean = 89.57 ± 16.16 ng/ml, median = 85.00 ng/ml, range = 45.00 ng/ml). The gene discussed is SERPINE1; the disease is systemic sclerosis.