SERPINE1 and systemic sclerosis: As shown in Figure 1C, patients with SSc had significantly higher PAI-1 concentrations (mean = 95.30 ± 22.80 ng/ml, median = 103 ng/ml, range = 107 ng/ml) than the healthy controls (mean = 66.90 ± 9.049 ng/ml, median = 67 ng/ml, range = 31 ng/ml).