Gene Ontology (GO) enrichment analysis revealed that the three most enriched GO terms in the three processes (BP, CC, MF) were ‘peptide serine dephosphorylation,’ ‘chromosome centromere region,’ and ‘chemokine receptor binding,’ indicating that PPP2R1A regulates protein dephosphorylation, cell cycle, and metabolic pathways, and synergistically drives lung adenocarcinoma progression with key genes such as PRPF31 and SCAF1 (Figures 5A-C). Here, SCAF1 is linked to lung adenocarcinoma.