IFNG and systemic lupus erythematosus: Previously, it was reported that AFs, alone or combined with an organic extract from A. tequilana, cause a decrease in joint inflammation and a reduction in the expression of some pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α and IFN-γ in a murine systemic autoimmunity type-SLE model (74).