These findings suggest that, in our AD model, pruritus is primarily mediated by pruritogenic factors other than IL-4, namely IL-22, IL-31, IL-33, substance P (SP) or thymic stromal lymphopoietin (TSLP) (89), and partially by histamine, as evidenced in the cetirizine-treated group. This evidence concerns the gene TAC1 and Alzheimer disease.