Intriguingly, while the overall MHC-I signaling was increased in treated ICC, the MHC-I signaling between malignant cells and CD8+ T cells was decreased (Figures 6C-E), consistent with the reduced expression levels of MHC-I molecules in GCP-treated malignant cells (Figure 5G). This evidence concerns the gene CD8A and intrahepatic cholangiocarcinoma.