The researchers constructed a novel MUC1-CAR-T cell by introducing multiple modifications, such as PD1 KO, IL-12 release, and TGFBR2 KO. The results showed that these CAR-T cells could not only play a powerful role in the local tumor microenvironment but also control distant metastases effectively. The gene discussed is TGFBR2; the disease is neoplasm.